Service Number£şABL014
Particle conjugation has been used in various biological applications. Biomolecules include antibodies, protein A/G, lectins, enzymes, toxins, and other proteins have all been conjugated to macroparticle or nanoparticle for diagnostic tests. Nanoparticle and microparticles are used in agglutination tests and assays, particle capture ELISA methods, lateral flow tests, solid phase assays, scintillation proximity assays, PCR, superparamagnetic-based assays and magnetic separation systems, biosensors, as enhancers of Ramam spectral signals, in light scattering assays, and as fluorescent labels or stains for detecting biological molecules.
Among them, Magnetic beads are used for separation procedures to enrich the population of a specific cell, or isolate biomolecules for purification purposes. Magnetic beads/particles are typically used as solid supports for the capture of DNA targets to improve sample throughput traditionally. However, it aggregate over time resulting in lower capture efficiency and obstruction of liquid handling devices. A new approach is developed-using magnetic beads and tagged oligonucleotide (ITO) probes. ITO and magnetic approach was more sensitive than a commercial magnetic bead method for the capture of target DNA from a pool of interfering genomic DNA.
(1)Progress of Conjugation
Activation of magnetic beads
Coupling reaction of probes and magnetic beads
Blocking active groups
Preservation
(2)Other Bioconjugation Portfolios:
Agarose-DNA
Agarose-Peptide
Oligo-qDot
Antibody/antigen-membrane
DNA-Magnetic Beads
DNA-Gold nanoparticles
Antibody-Gold
Lecint-Gold Conjugates
(Strep)avidin-Gold Conjugates
Oligonucleotide-Gold Conjugates
Fluorescent Labeled Latex
High binding capacity
Cost-effective
Less non-specific adsorption
High quality well-characterized conjugates
Flexible service options
The experience and ability of a dedicated team